Personal letters primarily of the Cooke family, from relatives and friends in West Virginia , Kentucky, and Missouri. On trip to see Buchanan's inauguration, March 7, 1857. On Sons of Termperance, February 23, 1850. On the trials of a young doctor in establishing practice at Bridgewater, Virginia, May 15, 1849. Letters from Missouri on living conditions, abolitionist activities, richness of soil, and opprotunity for success, 1853-1859.