This inventory, chiefly 1786-1815, represents three generations of the Preston family, and likewise can be divided into the following:

Items relating to William Preston (ca. 1729-1783), 1755-1782, primarily photostats of appointments to various county offices (coroner, sheriff and surveyor) and to positions in the Virginia militia; but also including original appointments, 1763 and 1776; a surveyor's entry; 1774; and letters, 1773-1782, to Preston concerning land, the Cherokee Indians and a court martial.

Items, 1785-1819, relating to William's sons, Francis Preston (1765- 1836), lawyer, member of the Virginia Legislature and the U.S. Congress; and his brother John Preston (1764-1827), member of the Virginia Assembly and long-time Treasurer of Virginia, including letters from John Preston to Francis Preston as well as correspondence of the two men with other people. Subjects covered in the letters include politics; the War of 1812; a carriage; the College of William and Mary; duels; the building of a house; and Indians. These papers also contain a certificate, 20 September 1793, of emancipation for a slave signed by Francis Preston; and his appointment of two military aides.

Items relating to the correspondence of William Campbell Preston (1764- 1860), son of Francis Preston, and a member of Congress from South Carolina, including a circular and letter, 1827, concerning protest by citizens of South Carolina of a protective tariff.